Tissue Disease

Name of disease 
Kindler Syndrome (Type of Epidermolysis Bullosa)


Symptoms

• Fluid-filled blisters on the skin, especially on the hands and feet due to friction

• Deformity or loss of fingernails and toenails

• Internal blistering, including on the vocal cords, esophagus and upper airway

• Skin thickening on the palms and the soles of the feet

• Scalp blistering, scarring and hair loss (scarring alopecia)

• Thin-appearing skin (atrophic scarring)

• Tiny white skin bumps or pimples (milia)

• Dental problems, such as tooth decay from poorly formed enamel

• Difficulty swallowing (dysphagia)

Prognosis
Life expectancy is normal.

Treatments
Esophageal strictures can be treated by balloon dilatation with fluoroscopic guidance.

Picture

Reference

• http://www.medicinenet.com/epidermolysis_bullosa_eb/article.htm 

• http://www.mayoclinic.org/diseases-conditions/epidermolysis-bullosa/basics/causes/con-20032497

• http://emedicine.medscape.com/article/1118967-overview

• http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=2908

Physiology Chapter 3 Question 15

Chapter 3 Question 15

Short Answer Essay Question: Why can an organ be permanently damaged if its cells are amitotic?



          An organ can be damaged if its cells are amitotic due to their inability to divide. Amitotic tissues are handicapped by injury because the cells that are lost through damage cannot be replaced by the same type of cells. The organ being unable to heal is extremely dangerous because it can lead to failure of  functioning and possibly, eventually death. For example, if a person repetitively gets heart attacks, the heart gets weaker and weaker each time. The heart cells cannot be replaced due to amitosis. 

Physiology Chapter 1 Question 4

Physiology Chapter 1 Question 4

Short Answer Essay Question: In addition to being able to metabolize, grow, digest food, and excrete wastes, what functions must an organism perform if it is to survive?

          In addition to being able to metabolize, grow, digest food, and excrete wastes, an organism requires a few more additional needs in order to survive. The human body have several factors called survival needs which include nutrients, oxygen, water and appropriate temperature and atmospheric pressure. The body needs nutrients for energy and cell building. Oxygen is used to release energy from foods.Without oxygen, nutrients would be of no use because the chemical reactions require oxygen. Oxygen is also about 20 percent of the air we breathe. Our body is made up of 60 to 80 percent of water. Water is also the base of bodily secretions and excretions. Other than that, body temperature must be maintained around 37 degrees Celsius. Most body heat is generated bt the activity of the skeletal muscles. Atmospheric pressure also plays a role in our body due to how we can carry our weight Breathing and the exchange of oxygen and carbon dioxide in the lungs depend on appropriate atmospheric pressure. Lastly,everything must be present in appropriate amounts because too much or too less of anything is life threatening. 

Physiology Chapter 3 Question 7

Chapter 3 Question 7

Short Answer Essay Question: Name the cellular organelles, and explain the function of each.

• Plasma membrane - defining the limits of the cell, "baggie"
• Nucleoli - sites where ribosomes are assembled 
• Cytoplasm - site of most cellular activities, "factory area"
• Mitochondria - supplies most of the ATP, "powerhouses" of the cell
• Ribosomes - actual sites of protein synthesis in the cell.
• Endoplasmic reticulum - serves as a mini-circulatory system for the cell because it provides a network of channels for carrying substances (primarily proteins) from one part of the cell to another
• Golgi Apparatus - modify and package proteins in specific ways, depending on their final destination (sent by the rough ER via transport vesicles)
• Lysosomes - membranous "bags" containing powerful digestive enzymes. (breakdown bodies)
• Peroxisomes - "disarm" dangerous free radicals
• Cytoskeleton - acts as a cell's "bones and muscles" by furnishing an internal framework that determines cell shape, supports other organelles, and provide the machinery needed for intracelllular transport and various types of cellular movements. 
• Centrioles -  direct the formation of the mitotic spindle

          

Physiology Chapter 3 Question 1

Chapter 3 Question 3 

Short Answer Essay Question: Although cells have differences that reflect their special functions in the body, what functional abilities do all cells exhibit?

          Although all cells have different functions, they all exhibit a few functions in order to survive. All cells exhibit the ability to grow, move, metabolize, intake food and transform it into energy, dispose of wastes, and respond to stimulus. Without all these abilities, a cell would not be able to perform what they are supposed to do and we would not be alive.

Physiology Chapter 1 Question 6

Chapter 1 Question 6

Short Answer Essay Question: What is the consequence of loss of homeostasis, or homeostatic imbalance?

          Homeostasis describes the body's ability to maintain relatively stable internal conditions even though the outside world is continuously changing. Homeostasis is so important that most diseases can be regarded as a result of its disturbance, a condition know as homeostatic imbalance. As we age, body organs start to deplete, and "our internal conditions become less and less stable." This makes us easily prone to illness. If our homeostasis is completely thrown off, we could very easily die due to our bodies having to stay in the state of equilibrium.